Objectives of Stage 3/2024

The main objective of the stage carried out in 2024 was to develop the experimental module of the portable device for the wearable sweat monitoring system. To achieve this objective the following activities were pursued:

• Integration of microfluidic membrane into multi-sensitive wearable system;
• Coupling and integrating the portable multisensor patch and the opto-electrochemical detector into a portable device;
• Design and development of functional hardware modules to be implemented in a bracelet;
• Testing and demonstrating the functionality under controlled and real conditions of the portable device for monitoring sweat analytes. Fine-tuning their technical performance;
• Filing a patent application;
• Dissemination and communication of results.

Results of Stage 3/2024

• Development of an experimental model of a portable and wearable device for monitoring sweat bioanalytes;
• Demonstration of the functionality of the portable and wearable system under controlled and real conditions;
• Filing 2 patent applications with OSIM;
• Dissemination of results – 2 ISI-listed articles were published, 1 workshop was organized, results were presented at four international conferences in the form of 2 posters and 5 oral presentations;
• Participation to 3 international invention fairs: ITE 2024, London, United Kingdom – Gold Medal, INOVA2024, Zagreb, Croatia – Silver Medal and KIDE2024, Kaohsiung, Taiwan;
• A working meeting was held at the Turkish partner, Necmettin Erbakan University, Konya;
• The Scientific and Technical Report has been drafted.

Publications

1. Assessment of Biogenic Amines Produced by Microorganisms as Food Spoilage Indicators by Sensitive Detection Using Portable Opto-Electrochemical Tools based on Biosensors – Lucian-Gabriel Zamfir, Iuliana Răut, Mariana Constantin, Nicoleta Olguța Corneli, Cristina Firincă, Maria-Luiza Jecu, Petru Epure, Mihaela Doni, Ana-Maria Gurban, Food Control, submitted for publication, currently in review process – FOODCONT-S-24-05980 (major corrections)
2. Natural polysaccharides- based hydrogels – a versatile tool for biomedical engineering development – Ioana Cătălina Gîfu, Cristina Lavinia Nistor, Cristian Petcu, Elvira Alexandrescu, Mihaela Doni, Lucian-Gabriel Zamfir, Ana-Maria Gurban, Polyssacharides – (to submission)

International Conferences and Inventions Fairs

1. Portable miniaturized bioanalytical tools for (bio)sensing applications – Ana-Maria Gurban – Invited speaker at 4th Local Government Congress of the Three Seas Regions, June 12-13, 2024, Lublin, Poland
2. Wearable multisensing patch based on swcnt-ptnps nanocomposite for clinical biomarkers monitoring from sweat – Lucian-Gabriel Zamfir, Saniye Soylemez, Dilek Soyler, Dilara Yeniterzi, Petru Epure, Cătălina Gîfu, Iuliana Răut, Mariana Constantin, Cristina Firincă, Nicoleta-Olguța Corneli, Maria-Luiza Jecu, Mihaela Doni, Ana-Maria Gurban, The International Symposium “PRIORITIES OF CHEMISTRY FOR A SUSTAINABLE DEVELOPMENT” Priochem XX, October16-18th, 2024, Bucharest, Romania – poster
3. Biosensing Approaches in the Development of Innovative Opto-Electrochemical Portable Tools for Food, Clinical and Environmental Applications – Ana-Maria Gurban, Lucian-Gabriel Zamfir, Petru Epure, Mihai Mitrea, Cristina Nistor, Iuliana Răut, Mariana Constantin, Cristina Firincă, Cătălina Gîfu, Cristian Petcu, Bogdan Trică, Maria-Luiza Jecu, Mihaela Doni – 6th International Congress on Biosensors, September 5-7, 2024, Konya, Turkey
4. Multisensing portable tool based on novel fullerenol derivatives for health status monitoring – Lucian-Gabriel Zamfir, Raluca Ianchiș, Saniye Soylemez, Salih Özçubukçu, Mihai Mitrea, Petru Epure, Cătălina Gîfu, Iuliana Răut, Mariana Constantin, Cristina Firincă, Maria-Luiza Jecu, Mihaela Doni, Ana-Maria Gurban, 6th International Congress on Biosensors, September 5-7, 2024, Konya, Turkey- poster. (Awarded – The second best Poster presentation)
5. Development of portable miniaturised opto-electrochemical analytical tools for biosensing applications – Ana-Maria Gurban*, Lucian-Gabriel Zamfir, Raluca Ianchiș†, Ioana Cătălina Gîfu, Iuliana Răut, Mariana Constantin, Cristina Firincă, Maria-Luiza Jecu, Mihaela Doni, 13th edition of Workshop on Biosensors and Bioanalytical Microtechniques in Environmental, Food and Clinical Analysis (BBMEC), May 20-23, 2024, Ceşme, Izmir, Turkey – oral presentation
6. Innovative nanomaterials based (bio)senors for health care applications – Lucian-Gabriel Zamfir, Raluca Ianchiș, Cătălina Gîfu, Petru Epure, Mihai Mitrea, Iuliana Răut, Cristina Firincă, Mariana Constantin, Maria-Luiza Jecu, Mihaela Doni, Ana-Maria Gurban, 13th edition of Workshop on Biosensors and Bioanalytical Microtechniques in Environmental, Food and Clinical Analysis (BBMEC), May 20-23, 2024, Ceşme, Izmir, Turkey – oral presentation
7. Designing of innovative hydrogel based on salecan for food packaging applications – Ioana Cătălina Gîfu, Raluca IANCHȘ†, Cristina Lavinia Nistor, Elvira Alexandrescu, Cristian Petcu, Lucian-Gabriel Zamfir, Mihaela Doni, Ana-Maria Gurban, 13th edition of Workshop on Biosensors and Bioanalytical Microtechniques in Environmental, Food and Clinical Analysis (BBMEC), May 20-23, 2024, Ceşme, Izmir, Turkey – poster presentation
8. Optimization study for indirect voltammetric determination of cortisol– Maria-Lorena Jinga, Daniel Preda, Mihaela Doni, Lucian-Gabriel Zamfir, Ana-Maria Gurban, Gabriela-Iulia David –  CHIMIA 2024 International Conference "New Trends in Applied Chemistry", at Ovidius University of Constanta, 30 May-01 June, 2024, Constanta, Romania – oral presentation
9. Procedure for manufacturing of a miniaturized nanocomposite based multisensing platform for the monitoring of clinically relevant biomarkers – Ana-Maria Gurban, Lucian-Gabriel Zamfir, Mihaela Doni, Catalina Gifu, Luiza Jecu, Iuliana Raut, Mariana Constantin, Cristina Firinca –International Invention and Trade Expo London, Kingston University- ITE2024, September 24-25, London, Great Britain
10. Procedure for manufacturing of a miniaturized nanocomposite based multisensing platform for the monitoring of clinically relevant biomarkers – Ana-Maria Gurban, Lucian-Gabriel Zamfir, Mihaela Doni, Catalina Gifu, Luiza Jecu, Iuliana Raut, Mariana Constantin, Cristina Firinca – 48th International Invention Show – INOVA2024, October 16-19, 2024, Zagreb, Croatia
11. Innovative fullerenol-hydrogels based nanomaterials for health diagnostic and care applications – Ana-Maria Gurban, Lucian-Gabriel Zamfir, Mihaela Doni, Mihai Mitrea, Petru Epure, Maria-Luiza Jecu, Cristina Firinca, Mariana Constantin, Iuliana Raut – 48th International Invention Show – INOVA2024, October 16-19, 2024, Zagreb, Croatia
12. Procedure for realization of a miniaturized electrochemical multisensing platform based on nanocomposites and enzymatic bioreceptors for the monitoring of clinically relevant biomarkers – Kaohsiung International Invention and Design EXPO (KIDE) 2024, Kaohsiung Exhibition Center (KEC), December 5-7, 2024, Qianzhen District, Kaohsiung, Taiwan
13. Procedure for realization of electrochemical biosensors based on nanomaterials for biogenic amines determination – Kaohsiung International Invention and Design EXPO (KIDE) 2024, Kaohsiung Exhibition Center (KEC), December 5-7, 2024, Qianzhen District, Kaohsiung, Taiwan

Awards

9th Annual Edition of the International Invention Innovation Competition in Canada, iCAN 2024, August 24, 2024 – Procedure for realization of electrochemical biosensors based on nanomaterials for biogenic amines determination – Lucian-Gabriel Zamfir, Ana-Maria Gurban, Mihaela Doni, Maria-Luiza Jecu, Iuliana Răut, Mariana Constantin, Maria-Lorena Jinga – Gold Medal

International Invention and Trade Expo London, Kingston University- ITE2024, September 24-25, London, Great Britain – Procedure for manufacturing of a miniaturized nanocomposite based multisensing platform for the monitoring of clinically relevant biomarkers – Ana-Maria Gurban, Lucian-Gabriel Zamfir, Mihaela Doni, Catalina Gifu, Luiza Jecu, Iuliana Raut, Mariana Constantin, Cristina Firinca – Gold Medal

I6The International Symposium “PRIORITIES OF CHEMISTRY FOR A SUSTAINABLE DEVELOPMENT” Priochem XX, 16-18th October, 2024, Bucharest, Romania – Zamfir Lucian – the award for recognizing the outstanding presentation given during the symposium

Working visits of partners

During September 04-09, 2024, the working group from the coordinator of this project, ICECHIM, together with a researcher from the partner company Chimgrup SRL, were on a working visit to Necmettin Erbakan University in Konya, Turkey, a partner in this project. During this visit, experimental determinations were carried out with the functionalized nanomaterial, fullerenol, synthesized by the Turkish partner. On this occasion, Mrs. Dr. Ana-Maria Gurban and Mr. Epure Petru gave presentations at the Sixth Biosensors Congress held in Konya, Turkey and participated with posters. Also, discussions were held between the Turkish person in charge of this project, Mrs. Assoc. Prof. Dr. Saniye Soylemez and Mrs. Dr. Gurban in view of participating in other international project competitions.

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